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Union University

College of Pharmacy

College of Pharmacy at Union

Pharmaceutics

Area Specialist: Dr. Richard Addo

In the past years, our research on Pharmaceutics has focused increasingly on the development of a drug delivery system, and specific formulation and microencapsulation of drugs and proteins. In this area of research, we use spray drying techniques to formulate these microparticles that have useful advantages over the conventional methods. We have also been involved in the formulation of microparticles containing drugs for the treatment of Age-Related Macular Degeneration (AMD). The reason that inspired us to work on this disease is that it is generally prevalent in geriatric patients, and we feel passionate about helping those that are helpless and needy.

Currently, we have included and transitioned to mostly working on analyzing the stability of various compounded formulations to determine their beyond-use-date (BUD) in order to ensure their safety when given to patients. This is achieved by first developing various analytical techniques but more especially using Ultra Performance Liquid Chromatography (UPLC) to simultaneously analyze these drugs, their metabolites, and their mixtures. This research has helped us secure grants from various stakeholders.

We are currently working with a funded grant on the evaluation of the stability of compounded pediatric drug suspensions in commercially available suspending vehicles. We plan to focus more on this as funding will allow. We have trained many students at a high level of scholarly activities, and we believe encouraging students to get involved in research is an essential contribution to research. Some of our works with our students and postdoctoral fellows have resulted in publications in peer-reviewed journals a book and some book chapters

CURRENT PUBLICATIONS

  • "Ocular Drug Delivery: Advances, Challenges and Applications" edited by Richard T. Addo. Published by Springer in November 2016.
  • Oluyemisi A. Bamiro*, Ruhi V. Ubale, Richard T. Addo, Chapter 1: Background of Ocular Drug Delivery: "Ocular Drug Delivery: Advances, Challenges and Applications. Edited by Richard T. Addo". Published by Springer in November 2016.
  • Henry Nettey*, Yvonne Darko, Oluyemisi A. Bamiro, and Richard Addo Chapter 3: Ocular Barriers: "Ocular Drug Delivery: Advances, Challenges and Applications. Edited by Richard T. Addo". Published by Springer in November 2016.
  • Ameeduzzafar Zafar, Javed Ahmad, Sohail Akhter, and Richard T. Addo*, Chapter 6: Nanotechnology for Transcorneal Drug Targeting in Glaucoma: Challenges and Progress: "Ocular Drug Delivery: Advances, Challenges and Applications. Edited by Richard T. Addo". Published by Springer in November 2016.
  • Ameeduzzafar Zafar, Javed Ahmad, Richard T. Addo, Sohail Akhter*, Chapter 9: Progress of Controlled Drug Delivery Systems in Topical Ophthalmology: Focus on Nano and Micro Drug Carriers: "Ocular Drug Delivery: Advances, Challenges and Applications. Edited by Richard T. Addo". Published by Springer in November 2016.
  • Addo RT et al, Chapter 1: Methods of Preparing Micro/Nanoparticles: "Nanoparticulate Vaccine Delivery Systems. Edited by Martin D'Souza". Published by Pan Stanford Publishing Pte. Ltd. June 2015
  • Ahmad J, Akhter S, Rizwanullah M, Khan MA, Pigeon L, Addo RT, Greig NH, Midoux P, Pichon C, Kamal MA. Nanotechnology based theranostic approaches in Alzheimer's disease management: Current status and future perspective. Curr Alzheimer Res. 2017;14(11):1164-1181
  • Rahman M, Beg S, Anwar F, Kumar V, Ubale R, Addo RT, Ali R, Akhter S. Liposome-Based Nanomedicine Therapeutics for Rheumatoid Arthritis. Crit Rev Ther Drug Carrier Syst. 2017;34(4):283-316.
  • Gala RP, Popescu C, Knipp GT, McCain RR, Ubale RV, Addo R, Bhowmik T, Kulczar CD, D'Souza MJ. Physicochemical and Preclinical Evaluation of a Novel Buccal Measles Vaccine. AAPS PharmSciTech. 2017 Feb;18(2):283-292.
  • Cotta KI, Addo RT, D'Souza MJ. "Evaluation of the Intestinal Colonizing Potential and Immunomodulating Capacity of Lactobacilli Microspheres" J Pharm Sci. 2016 May;105(5):1721-32. Epub 2016 Apr 1. Ahmad J, Amin S, Rahman M, Rub RA, Singhal M, Ahmad MZ, Rahman Z, Addo RT, Ahmad FJ, Mushtaq G, Kamal MA, Akhter S. "Solid Matrix Based Lipidic Nanoparticles in Oral Cancer Chemotherapy: Applications and Pharmacokinetics". Curr Drug Metab. 2015;16(8):633-44 Rahman M, Akhter S, Ahmad MZ, Ahmad J, Addo RT, Ahmad FJ, Pichon C. "Emerging advances in cancer nanotheranostics with graphene nanocomposites: opportunities and challenges". Nanomedicine (Lond). 2015 Aug; 10(15):2405-22. Epub 2015 Aug 7.
  • Addo RT, Yeboah KG, Siwale RC, Siddig A, Jones A, Ubale RV, Akande J, Nettey H, Patel NJ, Addo E, D'Souza MJ. "Formulation and characterization of atropine sulfate in albumin-chitosan microparticles for in vivo ocular drug delivery". J Pharm Sci. 2015 May; 104(5):1677-90. Epub 2015 Feb 4. Addo RT, Davis KR, Ubale R, Owen JS and Watkins EB. "Development and Validation of a UPLC Method for Rapid and Simultaneous Analysis of Proton Pump Inhibitors". AAPS PharmSciTech. 2015 Feb; 16 (1):30-4. Epub 2014 Aug 27.
  • Patel N, Addo RT, Ubale R, Uddin MN, D'Souza M, and Jobe L. "The effect of antisense to NF-?B in an albumin microsphere formulation on the progression of left-ventricular remodeling associated with chronic volume overload in rats". J Drug Target. 2014 Nov; 22(9):796-804. Epub 2014 Jun 3
  • Richard T. Addo, E. Blake Watkins, Joel S. Owen, Kenneth R. Davis, Ronald C. Bingham. "End of Supply Chain Screening to Assess Drug Product Quality in the U.S. Market - Omeprazole as a Case Study". Advances in Analytical Chemistry. 2013; 3(4): 48-53. 2163-2847
  • Siddig A, Musik L, Oyelowo O, Sun X, Addo R, Yeboah KG, "Formulation and characterization of novel riboflavin containing albumin/glycine microspheres" International Journal of Pharmacy and Integrated Life Sciences, August 2013
  • Yeboah KG, Akande J, Addo RT, Siwale RC, Aninkorah-Yeboah K, Siddig A. "In vitro and ex vivo characterization of lectin-labeled Mycobacterium tuberculosis antigen-containing microspheres for enhanced oral delivery". J Drug Target. 2014 Jan;22(1):34-47. Epub 2013 Aug 29
  • Aladin Siddig, Addo RT, and Kwame Yeboah. "Evaluation of over the counter vaginal lubricants nonoxymol-9 and KY Jelly as potential inducer of proinflammatory cytokines in human immune cells". European Journal of Chemistry. May 2013
  • Sheaffer EA, Addo RT. "Response to 'The need to evaluate question writers' views and the costs of constructed-response versus selected-response calculations questions". Am J Pharm Educ. 2013 May 13;77 (4):87
  • Sheaffer EA, Addo RT. "Pharmacy student performance on constructed-response versus selected-response calculations questions". Am J Pharm Educ. 2013 Feb 12; 77 (1):6.