Scholarship Project

Nathan Daniels

Associate Professor of Pharmaceutical Sciences

27 Results

Other Article(s)

• "Classics in Chemical Neuroscience: Amitriptyline," ACS chemical neuroscience. (January 2021) (with McClure EW)
• "Classics in Chemical Neuroscience: Pramipexole," ACS chemical neuroscience. (September 2020) (with Wilson SM, Wurst MG, Whatley MF)
• "DARK Classics in Chemical Neuroscience: Psilocybin," ACS chemical neuroscience. (October 2018)
• "Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling," Journal of medicinal chemistry. (July 2018) (with Abbott, J. R., Hodges, T. R., Patel, P. A., Kennedy, J. P., Howes, J. E., Akan, D. T., Burns, M. C., Sai, J., Sobolik, T., Beesetty, Y., Lee, T., Rossanese, O. W., Phan, J., Waterson, A. G., & Fesik, S. W.)
• "Cytochromes P450 1A2 and 3A4 Catalyze the Metabolic Activation of Sunitinib," Chemical research in toxicology. (February 2018) (with Amaya, G. M., Durandis, R., Bourgeois, D. S., Perkins, J. A., Abouda, A. A., Wines, K. J., Mohamud, M., Starks, S. A., Jackson, K. D.)
• "Classics in chemical neuroscience: levodopa," ACS chemical neuroscience. (October 2014) (with Whitfield, A. C., Moore, B. T.)
• "Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange," Proceedings of the National Academy of Sciences of the United States of America. (February 2014) (with Burns, M. C., Sun, Q., Camper, D., Kennedy, J. P., Phan, J., Olejniczak, E. T., Lee, T., Waterson, A. G., Rossanese, O. W., & Fesik, S. W. )
• "Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: development of a [3.3.0]-based series and other piperidine bioisosteres," Bioorganic & medicinal chemistry letters. (January 2014) (with Sheffler, D. J., Nedelcovych, M. T., Williams, R., Turner, S. C., Duerk, B. B., Robbins, M. R., Jadhav, S. B., Niswender, C. M., Jones, C. K., Conn, P. J., & Lindsley, C. W.)
• "Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design," Journal of medicinal chemistry. (January 2013) (with Friberg, A., Vigil, D., Zhao, B., Burke, J. P., Garcia-Barrantes, P. M., Camper, D., Chauder, B. A., Lee, T., Olejniczak, E. T., & Fesik, S. W.)
• "Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction. In Probe Reports from the NIH Molecular Libraries Program," National Center for Biotechnology Information. (March 2011) (with Manka, J., Dawson, E., Daniels, J. S., Southall, N., Jadhav, A., Zheng, W., Austin, C., Grembecka, J., Cierpicki, T., Lindsley, C. W., & Stauffer, S. R.)
• "Synthesis and SAR of N-(4-(4-alklylpiperazin-1-yl)phenyl)benzamides as muscarinic acetylcholine receptor subtype 1 (M1) anatgonists," Bioorganic & medicinal chemistry letters. (February 2010) (with Miller, N. R., Lee, D., Conn, P. J., & Lindsley, C. W.)
• "In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors," ACS chemical biology. (February 2010) (with Hao, J., Ho, J. N., Lewis, J. A., Karim, K. A., Gentry, P. R., Hopkins, C. R., Lindsley, C. W., & Hong, C. C.)
• "Progress toward the total synthesis of lucentamycin A: total synthesis and biological evaluation of 8-epi-lucentamycin A," The Journal of organic chemistry. (February 2009) (with Melancon, B. J., Wang, E. A., Crews, B. C., Marnett, L. J., Sulikowski, G. A., & Lindsley, C. W.)
• "Total synthesis of Ciliatamides A-C: stereochemical revision and the natural product-guided synthesis of unnatural analogs," Organic letters. (October 2008) (with Lewis, J. A., Lindsley, C. W.)
• "A new catalytic Cu(II)/sparteine oxidant system for beta,beta-phenolic couplings of styrenyl phenols: synthesis of carpanone and unnatural analogs," Organic letters. (September 2008) (with Fadeyi, O. O., & Lindsley, C. W.)
• "Synthesis and SAR of analogs of the M1 allosteric agonist TBPB. Part II: Amides, sulfonamides and ureas--the effect of capping the distal basic piperidine nitrogen," Bioorganic & medicinal chemistry letters. (September 2008) (with Miller, N. R., Bridges, T. M., Brady, A. E., Conn, P. J., & Lindsley, C. W.)
• "Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties," Bioorganic & medicinal chemistry letters. (September 2008) (with Bridges, T. M., Brady, A. E., Kennedy, J. P., Miller, N. R., Kim, K., Breininger, M. L., Gentry, P. R., Brogan, J. T., Jones, C. K., Conn, P. J., & Lindsley, C. W.)
• "Application of combinatorial chemistry science on modern drug discovery," Journal of combinatorial chemistry. (January 2008) (with Kennedy, J. P., Williams, L., Bridges, T. M., Weaver, D., & Lindsley, C. W.)
• "A new, non-SSRI mechanism of action for Prozac," Current topics in medicinal chemistry. (January 2007) (with Lindsley, C. W.)

Presentation(s)

• "Development of Allosteric Modulators of MC4R for the Treatment of Obesity" (with Naguib, M. A.; Hedges, W. S.; McArtney, G. E.; Leaver, A. G.; Abdelmessih, B. A.; Fasig, Z. D.; Gimenez, L. E.; Cone)
  ACS Southeast Regional Meeting, Savannah, GA. (October 2019)
• "Development of Allosteric Modulators of MC4R for the Treatment of Obesity" (with Naguib, M. A.; Hedges, W. S.; McArtney, G. E.; Leaver, A. G.; Abdelmessih, B. A.; Fasig, Z. D.; Gimenez, L. E.; Cone, R. D.)
  Christian Scholar’s Conference, Nashville, TN. (June 2018)
• "Metabolic Activation of Sunitinib: Implications for Sunitinib-Induced Toxicities" (with Amaya, G. M.; Durandis, R.; Wines, K. J.; Abouda, A. A.; Starks, S. A.; Jackson, K. D. )
  Christian Scholar’s Conference, Nashville, TN. (June 2018)
• "Metabolic Activation of Sunitinib: Implications for Sunitinib-Induced Toxicities" (with Jackson, K. D., Amaya, G. M., Durandis, R., Wines, K .J., Abouda, A. A., Starks, S. A.)
  American Association for Cancer Research Annual Meeting, Chicago, IL. (April 2018)
• "Harnessing modern drug discovery to develop potential therapies for critical medical needs" Tennessee State University Deans lecture series. (October 2014)
• "Discovery of interfacial binders to the K-Ras/SOS complex" (with Burns, M. C.; Sun, Q.; Kim, H.-Y.; Lee, T.; Waterson, A. G.; Rossanese, O. W.; Phan, J.; Fesik, S. W. )
  Vanderbilt Ingram Cancer Center Retreat. (May 2012)
• "Total synthesis and biological evaluation of 8-epi-Lucentamycin A" ACS Southeast Regional Meeting, San Juan, Puerto Rico. (November 2008)
• "Total synthesis of Lucentamycins" (with Lindsley, C.W. )
  ACS National Meeting, New Orleans, LA. (April 2008)