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Richard Addo

Professor of Pharmaceutical Sciences

About

Dr. Richard Tettey Addo, B. Pharm., Ph.D., graduated with his Bachelor of Science degree in Pharmacy (B. Pharm) from the University of Science and Technology, Ghana in 2002. After practicing Pharmacy in a variety of settings he joined Mercer University College of Pharmacy and Health Sciences, where he earned a Ph.D. in Pharmaceutical Sciences in 2008. Prior to joining Union University as Associate Professor of Pharmaceutics, Dr. Addo served as an Assistant Professor of Pharmaceutical Sciences at the Bernard J. Dunn School of Pharmacy (Shenandoah University) in 2008 and at the same time also served as an Adjunct Professor of Pharmacogenomics at the George Washington University School of Medicine and Health Sciences. He has also served as a Graduate Research and Teaching Assistant at Mercer University. Dr. Addo teaches pharmaceutical calculations, Pharmaceutics, sterile and non-sterile compounding to first and second year pharmacy students.
Some of his research interests include stability of compounded formulations, dosage forms and drug delivery systems. This includes a broad perspective of delivering various small molecules and large molecules (e.g. vaccines and proteins) in their most stable form to treat numerous diseases such as inflammations and cancers that have taken a major toll in the human population. This involves creating a delivery platform of formulation and efficient processing of microparticles and nanoparticles for protein pharmaceuticals, controlled release biodegradable and targetable particle drug delivery systems prepared by one-step spray drying. His long-term research goal is to develop a strategy where a vaccine, when formulated in a delivery vehicle (micro- and nanoparticles with specific excipients/adjuvants) can behave in a desired manner to stimulate the body’s immune recognition and facilitate a long lasting potent memory to that disease. He has published a number of peer reviewed scientific articles and had poster presentations at both regional and national scientific meetings.
Besides chasing after his three children, Dr. Addo enjoys playing ping pong (table tennis) with his students and friends.

Education

  • Ph.D, Mercer University

  • B.S., University of Science & Technology, Ghana

Scholarship

Books

Articles

  • Emerging advances in cancer nanotheranostics with graphene nanocomposites: opportunities and challenges. (2015)

    Nanomedicine (Lond)

  • Formulation and characterization of atropine sulfate in albumin-chitosan microparticles for in vivo ocular drug delivery. (2015)

    J Pharm Sci.

  • Development and Validation of a UPLC Method for Rapid and Simultaneous Analysis of Proton Pump Inhibitors. (2015)

    AAPS PharmSciTech

  • Solid Matrix Based Lipidic Nanoparticles in Oral Cancer Chemotherapy: Applications and Pharmacokinetics (2015)

    Curr Drug Metab.

  • The effect of antisense to NF-?B in an albumin microsphere formulation on the progression of left-ventricular remodeling associated with chronic volume overload in rats. (2014)

    J Drug Target

  • In vitro and ex vivo characterization of lectin-labeled Mycobacterium tuberculosis antigen-containing microspheres for enhanced oral delivery (2014)

    J Drug Target

  • Formulation and characterization of novel riboflavin containing albumin/glycine microspheres (2013)

    International Journal of Pharmacy and Integrated Life Sciences

  • Evaluation of over the counter vaginal lubricants nonoxymol-9 and KY Jelly as potential inducer of proinflammatory cytokines in human immune cells (2013)

    European Journal of Chemistry

  • Response to ‘The need to evaluate question writers’ views and the costs of constructed-response versus selected-response calculations questions” (2013)

    Am J Pharm Educ.

  • Pharmacy student performance on constructed-response versus selected-response calculations questions (2013)

    Am J Pharm Educ.

  • End of Supply Chain Screening to Assess Drug Product Quality in the U.S. Market – Omeprazole as a Case Study (2013)

    Advances in Analytical Chemistry

  • Spray-dried doxorubicin-albumin microparticulate systems for treatment of multidrug resistant melanomas (2011)

    Journal of Drug Targeting

  • Formulation, Characterization, and Testing of Tetracane Hydrochloride-Loaded Albumin-Chitosan Microparticles for Ocular Drug Delivery (2010)

    Journal of Microencapsulation

  • Targeted Delivery of Antigens to the Gut-Associated Lymphoid Tissues: 2. Ex vivo Evaluation of Lectin-labeled Albumin Microspheres for Targeted Delivery of Antigens to the M cells of the Peyer’s Patch (2010)

    Journal of Microencapsulation

  • The effect of intracellular antioxidant delivery (catalase) on hydrogen peroxide and pro-inflammatory cytokine synthesis: a new therapeutic horizon (2009)

    Journal of Drug Targeting

  • The effect of intracellular delivery of catalase and antisense oligonucleotide to NF-kappaB using albumin microcapsules in the endotoxic shock model (2009)

    Journal of Drug Targeting

  • Formulation and characterization of catalase in albumin microspheres (2008)

    J Microencapsul

  • Treatment of adjuvant arthritis using microencapsulated antisense NF-kappaB oligonucleotides (2008)

    J Microencapsul

Presentations

  • Ex Vivo Evaluation of Inhibition of LPS-Induced Choroidal Neovascularization into the Retinal Epithelium with Antioxidant Thymoquinone in L-a Phosphatidylcholine-Chitosan Microparticles (2015)

    AAPS Meeting

  • Needleless Measles Vaccine Delivery: Preclinical Evaluation of Oral Disintegrating Films in a Juvenile Pig Model (2015)

    AAPS Meeting

  • Development of Nano-Sized Particles Containing Anti-Oxidant for the Treatment of Age-Related Macular Degeneration (AMD) (2015)

    Union University PEW Luncheon

  • Formulation and Characterization of Thymoquinone-Loaded Microparticles for Treatment of Age Related Macular Degeneration. (2014)

    American Association of Pharmaceutical Scientist, Annual Conference

  • Development and Validation of a UPLC Method for Rapid and Simultaneous Analysis of Proton Pump Inhibitors. (2014)

    American Association of Pharmaceutical Scientists Annual Meeting and Exposition

  • Ocular Delivery of peptides and proteins. (2014)

    5th World Congress on Biotechnology

  • Formulation and Characterization of Albumin/Glycine Microspheres Encapsulated with Riboflavin as a model drug (2012)

    AAPS at the McCormick Place

  • Formulation, Characterization and in vitro evaluation of Resveratrol Loaded Glycine Microspheres. (2011)

    AAPS Annual Meeting

  • Formulation of Cross-linked Albumin Nanospheres via the One Step Spray Drying Process (2011)

    3rd Annual Georgia Nanotechnology and Infectious Disease Symposium

  • A Comparative Study of Question Types in Pharmaceutical Calculations and Pharmaceutics (2010)

    AACP Annual Meeting

  • Development and Validation of HPLC Assay for Prednisolone in Pluronic Lecithin Organogel (PLO) Stability Study (2010)

    Shenandoah University Research Symposium

  • Development and Validation of Stability-indicating HPLC Method to Determine the Stability of Promethazine in Pluronic Lecithin Organogel (PLO) (2010)

    Shenandoah University Research Symposium

  • To quantitatively establish ketoprofen stability in PLO by developing and validating a stability-indicating HPLC method. (2010)

    Shenandoah University Research Symposium

  • Evaluation of microparticulate based atropine formulations for its mydriatic effect (2008)

    American Association of Pharmaceutical Scientists, Annual Conference

  • Evaluation of the effect of microencapsulated antisense oligonucleotide to NF-KB on B-16 melanoma-induced tumor development and regression (2008)

    American Association of Pharmaceutical Scientists, Annual Conference

  • The Effects of Sustained Release NF-kB Anti-Sense Microencapsulated Albumin Microspheres on Left Ventricular Remodeling Associated with Chronic Volume Overload in Rats (2008)

    American Association of Pharmaceutical Scientists, Annual Conference

  • Evaluation of the effect of tetracaine microparticles formulations (2007)

    American Association of pharmaceutical Scientist, Annual Conference

  • Evaluation of the effect of the microencapsulated anti-sense oligonucleotide to NF-kappaB on tumor development and regression (2007)

    American Association of pharmaceutical Scientist, Annual Conference

Dissertations

  • Development and Characterization of Novel Encapsulated Ocular Drug Delivery Formulations (2008)

    Mercer University

Awards

  • Research Grant (2013)

    • Addo, RT and Ubale R. “Development of Nano-sized Particles Containing Anti-oxidant for the Treatment of Age Related Macular Degeneration”. Funded by Union University Pew Research Program (Principal Investigator)

  • Grant (2012)

    • Addo RT, Watkins EB, Owen JS. Accelerated Stability Testing of Compounded Drugs “A Research Proposal to evaluate the stability of various compounded drugs and assigning the BUD to the preparation” – amount $5141.70. Betamethasone Sodium Phosphate /Betamethasone Acetate drug Suspension funded on August 2012 by Main street Pharmacy, Newbern TN – (Principal Investigator)

  • Research Grant (2012)

    Addo R.T., Owen J.S., Watkins E.B., Phillip A., “Is there Medicine in the Medicine?” A Research Proposal to evaluate marketed products for drug content. Ronald Bingham, M.D., EMG Clinics of Tennessee. PLLC. $11,270.64

  • Research Grant (2010)

    Peacock, G, Addo, RT. “The Stability of Various (five different) Drugs Compounded in PLO gel”, IACP, International Academy of Compounding Pharmacist, $9,400.00

  • Outstanding Poster and Presentation Award (2008)

    o Outstanding Poster and Presentation Award Winner at Graduate Research Association of Students of Pharmacy (GRASP), Florida A. and M. University, Tallahassee, Florida on June 7, 2008. Poster entitled "Development and Evaluation of Microparticulate Based Atropine Formulations for its Mydriatic Effect"