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Nathan Daniels

Professor of Pharmaceutical Sciences

About

Dr. Nathan Daniels, Ph.D., graduated with his Bachelor of Science in Chemistry at the Ohio State University in 2003. While working for Vanderbilt University as an Undergraduate and Graduate Student Mentor, Dr. Daniels finished his Ph.D. in Organic Chemistry at Vanderbilt University in 2010, followed by his Postdoctoral Fellowship, Medicinal Chemistry at Vanderbilt University, Nashville, TN, in 2012. Prior to joining Union University as Associate Professor of Pharmaceutical Sciences, Dr. Daniels served as an Assistant Professor of Pharmaceutical Sciences at Lipscomb University College of Pharmacy in Nashville, TN. Dr. Daniels is currently a member of the American Chemical Society, American Association of Colleges of Pharmacy, Tennessee Pharmacists Association, Academic Drug Discovery Consortium, American Association of Pharmaceutical Scientists, Phi Delta Chi Professional Pharmacy Fraternity, Council on Undergraduate Research.

Education

  • Ph.D in Organic Chemistry, Vanderbilt University

  • B.S. in Chemistry, Ohio State University

Scholarship

Articles

  • Classics in Chemical Neuroscience: Amitriptyline (2021)

    ACS chemical neuroscience

  • Classics in Chemical Neuroscience: Pramipexole (2020)

    ACS chemical neuroscience

  • DARK Classics in Chemical Neuroscience: Psilocybin (2018)

    ACS chemical neuroscience

  • Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling (2018)

    Journal of medicinal chemistry

  • Cytochromes P450 1A2 and 3A4 Catalyze the Metabolic Activation of Sunitinib (2018)

    Chemical research in toxicology

  • Classics in chemical neuroscience: levodopa (2014)

    ACS chemical neuroscience

  • Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange (2014)

    Proceedings of the National Academy of Sciences of the United States of America

  • Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: development of a [3.3.0]-based series and other piperidine bioisosteres (2014)

    Bioorganic & medicinal chemistry letters

  • Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design (2013)

    Journal of medicinal chemistry

  • Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction. In Probe Reports from the NIH Molecular Libraries Program (2011)

    National Center for Biotechnology Information

  • In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors (2010)

    ACS chemical biology

  • Synthesis and SAR of N-(4-(4-alklylpiperazin-1-yl)phenyl)benzamides as muscarinic acetylcholine receptor subtype 1 (M1) anatgonists (2010)

    Bioorganic & medicinal chemistry letters

  • Progress toward the total synthesis of lucentamycin A: total synthesis and biological evaluation of 8-epi-lucentamycin A (2009)

    The Journal of organic chemistry

  • Total synthesis of Ciliatamides A-C: stereochemical revision and the natural product-guided synthesis of unnatural analogs (2008)

    Organic letters

  • A new catalytic Cu(II)/sparteine oxidant system for beta,beta-phenolic couplings of styrenyl phenols: synthesis of carpanone and unnatural analogs (2008)

    Organic letters

  • Synthesis and SAR of analogs of the M1 allosteric agonist TBPB. Part II: Amides, sulfonamides and ureas–the effect of capping the distal basic piperidine nitrogen (2008)

    Bioorganic & medicinal chemistry letters

  • Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties (2008)

    Bioorganic & medicinal chemistry letters

  • Application of combinatorial chemistry science on modern drug discovery (2008)

    Journal of combinatorial chemistry

  • A new, non-SSRI mechanism of action for Prozac (2007)

    Current topics in medicinal chemistry

Presentations

  • Harnessing modern drug discovery to develop potential therapies for critical medical needs (2014)

    Tennessee State University Deans lecture series

  • Discovery of interfacial binders to the K-Ras/SOS complex (2012)

    Vanderbilt Ingram Cancer Center Retreat

  • Total synthesis and biological evaluation of 8-epi-Lucentamycin A (2008)

    ACS Southeast Regional Meeting

  • Total synthesis of Lucentamycins (2008)

    ACS National Meeting